Laboratory Corporation of America Senior Scientist - NGS Assay Development in San Diego, California
Sequenom, a wholly-owned subsidiary of Laboratory Corporation of America Holdings (LabCorp), is a CAP accredited and CLIA-certified molecular diagnostics laboratory, dedicated to the development and commercialization of laboratory-developed tests (LDTs) for prenatal conditions, cancer, and other diseases.
As a member of the R&D Diagnostic Development team, the Senior Scientist will lead laboratory initiatives with responsibilities including the planning, execution, and analysis of assay development projects with a particular focus on innovative and challenging programs like liquid biopsy. The ideal candidate will have extensive knowledge of molecular biology and biochemistry as well as a proven track record in development of novel nucleic acid detection assays. Experience with the analysis of complex genomic data, in particular NGS and/or microarray data, is preferred. Understanding of the biology of cancer as well as the challenges and limitations of low frequency variant detection is a plus. This is an exciting opportunity to be part of a dynamic R&D team and have the opportunity to participate in novel technology development.
Design cutting-edge assays and experiments, execute experimental protocols, and analyze data for review
Contribute to the team focusing on the development of liquid biopsy and other molecular diagnostic assays
Develop next generation sequencing assays and perform data analysis/interpretation
Conceive and design model systems for proof-of-concept studies
Design and execute appropriate analytical verification studies
Perform data analysis with graphical representations of findings using appropriate software (R, Excel, JMP)
Present data clearly and concisely at departmental meetings and project meetings
Develop target enrichment approaches utilizing multiplex PCR and/or capture methods
Participate and present findings at conferences
Publish scientifically relevant data in peer reviewed journals
Participate in the development of patent applications, if applicable
Independently and/or collaboratively conceive, initiate, and apply for the acceptance of new projects
Document all work in the form of laboratory notebook, study reports, summary reports and presentations
PhD in Molecular Biology, Genetics or related field and 5-10 years' industrial experience in an applied research and/or development environment
Experience with optimization of next generation sequencing-based assays
Experience with targeted NGS enrichment technologies
Experience with oncology, prenatal, and/or infectious disease assay development preferred.
Strong background in experimental design and assay optimization.
Strong background in data analysis using statistical software packages including R or JMP
Project and resource management experience a plus
As an EOE/AA employer, the organization will not discriminate in its employment practices due to an applicant's race, color, religion, sex, national origin, sexual orientation, gender identity, disability or veteran status.